As you may guess from the title-Elizabeth Tudor is born as boy-and that obviously makes Anne Boleyn 10 feet tall and bulletproof, but not forever. Said boy fell ill and dies aged 10 and Henry VIII is once again without male heir. What would he do? He can't hope to have another child with Anne (say, that Edward was their only child to survive infancy) who is in her 40s, but with his own health not being particulary good at this point younger wife may not solve his problem. But wouldn't he still try? If so, he'd be even more in hurry than IOTL. What happens to Anne? Same thing as IOTL, just later? Meanwhile, if Henry is unable to have more children, would he eventually accept Mary as heiress?